Breakthrough Discovery Changes Our Basic Concept of Gene Expression. RNA Has a Regulatory Role in DNA Transcription!

Core dogma is a one-way mechanism in which gene information flows into proteins: DNA RNA protein. A recent study found that RNA can alter how DNA is transcribed.

An unexpected research published in Science on January 16, 2020 demonstrated that messenger RNA, a fundamental courier that transfers information from DNA to proteins, has his own impact on protein production via a reversible methylation process.

This revolutionary study discovered a number of "reader" proteins that detect methylation mRNA and alter target mRNA stability and translation. A similar methylation process has been reported in chromosome-associated regulatory RNAs, or carRNAs. These carRNAs, however, do not code for protein and do not play a direct role in protein translation. They really have control over how DNA is stored and transcribed.


This ground-breaking discovery will almost certainly have far-reaching implications for our understanding of human sickness and pharmaceutical design.


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