Mutation in non-coding Genome May Lead to Cancer Progression. One Big Step towards Overlooked Areas of DNA.

Previous cancer research has concentrated on protein-coding DNA regions. A new study has proven a link between non-coding DNA mutations and cancer development.

On January 17, 2020, an unprecedented study published in Molecular Cell revealed that non-coding genomic alterations may contribute to cancer development and progression.

Researchers examined over 100,000 portions of each patient's genome, paying special attention to non-coding genome regions that interact with genes via the three-dimensional genome. Scientists discovered that one of the 30 crucial areas has an important role in the regulation of a known anti-tumor gene in cancer cells, despite the fact that there are more than 250,000 base pairs between the anti-tumor gene and this key non-coding region.

This study emphasizes the need of focusing on non-coding genomes, which may be linked to cancer growth and progression.

References


Comments

Post a Comment

Popular posts from this blog

First Living Robots from Stem Cells. Are We Dreaming?

Most of us are aware of stem cells' remarkable capacity to develop into other cells such as blood, brain, or liver cells. However, did you know that stem cells can be transformed into living robots? An extraordinary research published in the Proceedings of the National Academy of Sciences on January 13, 2020, shown that frog stem cells may be transformed into the world's first living, self-healing robots. These living machines are known as xenobots because they are derived from the stem cells of the African clawed frog (Xenopus laevis), and the term "xenobots" comes from the combination of Xenopus and robots. These xenobots are projected to have a significant influence not just on targeted therapy, but also on human health and wellbeing. References https://www.pnas.org/content/early/2020/01/07/1910837117 https://edition.cnn.com/2020/01/13/us/living-robot-stem-cells-intl-hnk-scli-scn/index.html https://www.livescience.com/frogbots-living-robots.html https://www.uvm.edu...
Read more

Researchers Found an Indicator of Severity of COVID-19. Soluble Circulating Protein May Be the Clue.

A new study published on April 30, 2020 in Journal Critical Care   indicated that the protein soluble urokinase plasminogen activator receptor (suPAR) may assist researchers anticipate who is likely to have more severe COVID-19 symptoms. In other words, suPAR may be regarded as a proxy measure of COVID-19 severity. The researchers examined data from 57 patients at Greece's University of Athens Medical School and 5 COVID-19 patients at Rush University Medical Center. They discovered that patients with greater amounts of suPAR in their blood needed intubation sooner than individuals with lower levels of suPAR. This is the first publication to suggest that suPAR is higher in COVID-19 and may be indicative of COVID-19 severity. This study is important not just for identifying patients who are more likely to require immediate intensive care, but also for identifying individuals who can safely manage the condition at home. References https://www.medicalnewstoday.com/articles/study-sugges...
Read more

Kawasaki-like Disease is seen in Some Children with COVID-19

On May 13, 2020, a stunning research published in Lancet   discovered that unique severe Kawasaki-like disease in children caused by COVID-19 was reported in several nations including Italy and the United Kingdom. This highlights the possibility of a link between COVID-19 and Kawasaki-like illness. Although SARS-CoV-2 infection affects children infrequently, a tiny fraction of them develop Kawasaki-like illness. Kawasaki illness, a rare acute paediatric vasculitis, mostly affects children under the age of five. Coronary artery aneurysms are the most common complication of Kawasaki illness. The presence of persistent fever, lymphadenopathy, conjunctival injection, and alterations to the mucosae and extremities is used to make the diagnosis (swollen extremities). The absence of a good diagnostic test impedes the diagnosis of Kawasaki illness, which is most reliant on laboratory and clinical criteria. Ongoing research is attempting to determine the link between COVID-19 and the Kawasa...
Read more