Relationship between Gut Microbiota and Parkinson's Disease. A Step Closer to the Treatment of Parkinson's Disease

Recent research has found a link between gut microbiota (the bacterial population that lives in our intestine) and Parkinson's disease. However, it is still unknown how gut microbiota influences neurodegenerative diseases in Parkinson's disease.

An interesting new research published in Cell Reports on January 14, 2020 discovered that a common gut bacterium (Bacillus subtilis) that promotes digestive health may also help guard against Parkinson's disease.

The probiotic Bacillus subtilis strain PXN21 can delay and even reverse the accumulation of a harmful protein known as -synuclein, which is linked to Parkinson's disease. The -synuclein protein accumulates, generating toxic clumps that are linked to nerve cell death. Probiotics are living microorganisms that can enhance or restore normal gut flora.

This innovative investigation was carried out using roundworms (Caenorhabditis elegans) that had been genetically engineered to generate the human variant of -synuclein. Introducing Bacillus subtilis strain PXN21 was able to clean up -synuclein aggregation, alleviating Parkinson's disease movement symptoms.


The outcomes of this study indicate the potential of employing probiotics to treat Parkinson's disease in the future.



References

https://www.news-medical.net/news/20200114/Parkinsone28099s-disease-could-be-prevented-by-gut-microbes.aspx


https://www.ajmc.com/newsroom/protein-tested-in-roundworms-protects-against-parkinson-disease-


https://www.cell.com/action/showPdf?pii=S2211-1247%2819%2931743-7


https://www.nutraingredients.com/Article/2020/01/16/Probiotic-strain-may-protect-against-Parkinson-s-disease-early-data-suggests







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